3.17B - ABO blood-group inheritance

3.17B - ABO blood-group inheritance

Extend simple genetic crosses to a gene with three alleles in the population. Use ABO blood groups to distinguish codominance from dominance and work out which blood groups offspring could inherit.

3.17B — ABO blood-group inheritance

Biology-only (Foundation and Higher): 3.17B

The ABO blood-group gene shows two features that extend the ordinary two-allele, complete-dominance model.

Multiple alleles means that more than two alleles of one gene exist in the population. The main ABO alleles are IAI^A, IBI^B and IoI^o. A person still inherits only two alleles, one from each parent.

Codominance means that two different alleles are both expressed in a heterozygote. IAI^A and IBI^B are codominant with each other, so IAIBI^A I^B produces blood group AB rather than A, B or a blended intermediate. The IoI^o allele is recessive to both IAI^A and IBI^B.

GenotypeBlood-group phenotype
IAIAI^A I^AA
IAIoI^A I^oA
IBIBI^B I^BB
IBIoI^B I^oB
IAIBI^A I^BAB
IoIoI^o I^oO

Worked example: producing all four blood groups

A parent with heterozygous group A has genotype IAIoI^A I^o. A parent with heterozygous group B has genotype IBIoI^B I^o.

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