3.17B - ABO blood-group inheritance
Extend simple genetic crosses to a gene with three alleles in the population. Use ABO blood groups to distinguish codominance from dominance and work out which blood groups offspring could inherit.
3.17B — ABO blood-group inheritance
Biology-only (Foundation and Higher): 3.17B
The ABO blood-group gene shows two features that extend the ordinary two-allele, complete-dominance model.
Multiple alleles means that more than two alleles of one gene exist in the population. The main ABO alleles are , and . A person still inherits only two alleles, one from each parent.
Codominance means that two different alleles are both expressed in a heterozygote. and are codominant with each other, so produces blood group AB rather than A, B or a blended intermediate. The allele is recessive to both and .
| Genotype | Blood-group phenotype |
|---|---|
| A | |
| A | |
| B | |
| B | |
| AB | |
| O |
Worked example: producing all four blood groups
A parent with heterozygous group A has genotype . A parent with heterozygous group B has genotype .
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